Key result
Immature canine LVs show ~5% shorter sarcomere lengths than adult dogs, indicating resistance to stretch.
Why the study?
The relation between sarcomere length, pressure-volume curves, and geometry in the immature canine left ventricle compared to adult hearts was not fully characterized.
Absolute Event Rate: 2.21% vs 2.33%
p-value: p=< 0.05
Immature canine left ventricles show reduced compliance and resist stretch at higher pressures compared to adults, suggesting better protection against volume overloads.
Authors
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Immature canine myocardium resists stretch; leaves open whether similar compliance protects human neonates from volume overload.
Spotnitz et al. (1979) studied Left ventricular ultrastructure and function (n=18). Left ventricular fixation at predetermined pressures (0-30 mm Hg) vs. Adult dogs (previous results) was evaluated on Average midwall sarcomere length at fixation pressures between 15 and 30 mm Hg (µm) (p=< 0.05). In immature canine left ventricles fixed between 15 and 30 mm Hg, average sarcomere length was significantly shorter than in adult dogs (2.21 vs 2.33 µm, P<0.05), indicating resistance to stretch.
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