Key result
Adult rabbit ventricular myocytes exhibited significantly larger size, longer rest sarcomere lengths, and greater amount and velocity of sarcomere shortening compared to immature myocytes.
Developmental changes in the ultrastructure and compartmentalization of the sarcoplasmic reticulum contribute to increased contractility in adult compared to immature rabbit ventricular myocytes.
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Rabbit myocyte maturation data extend developmental contractility models; leaves open human pediatric translation.
Nassar et al. (1987) studied this question. Adult developmental stage vs. Three-week-old (immature) developmental stage was evaluated on Sarcomere shortening and ultrastructure. Adult rabbit ventricular myocytes exhibited significantly larger size, longer rest sarcomere lengths, and greater amount and velocity of sarcomere shortening compared to immature myocytes.
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