Key result
Elevated POSTN and decreased B-cell infiltration predict lung adenocarcinoma overall survival with ~90% 1-year NPV.
Why the study?
Useful prognostic factors of lung adenocarcinoma were not well identified by evaluating periostin expression and immune cell infiltration using public data.
Are POSTN expression activity and immune cell infiltration prognostic factors for lung adenocarcinoma?
Observational
Are POSTN expression activity and immune cell infiltration prognostic factors for lung adenocarcinoma?
Elevated POSTN expression and decreased B-cell infiltration are identified as important prognostic factors for lung adenocarcinoma.
Answers are grounded in this paper and cite their sources.
May refine prognosis in lung adenocarcinoma; leaves open whether targeting POSTN alters outcomes.
The objective of this study is to identify useful prognostic factors of lung adenocarcinoma (LUAD) by evaluating the changes of periostin (POSTN) expression activity and immune cell infiltration using public data repositories. The gene and protein expressions of POSTN in LUAD were collected and analyzed from Ualcan and Human Protein Atlas online database. The cell infiltration data of immune cells in LUAD patients were retrieved and processed using the TIMER tool. Cox regression analysis was employed to screen and characterize prognosis factors, Kaplan-Meier Plotter was used to analyze the survival curve of LUAD patients, and receiver operating characteristic curve was used to calculate the relationship between temporal POSTN expressions and the prognosis of LUAD. The expression activity of POSTN in LUAD was higher than that in normal tissues. With the exception of B cell which showed opposite correlationship, the infiltration of most immune cells, namely CD8+ T cells, macrophages, neutrophils, and dendritic cells, was positively correlated with the POSTN expression activity. Together, our investigation suggested that the POSTN expression activity and B-cell infiltration were the prognostic factors of LUAD. In addition, the 1-year negative predictive value of the POSTN expression activity for overall survival, disease-free survival, and progression-free interval was 0.902, 0.926, and 0.838, respectively. Along with decreased B-cell infiltration, the elevated expression of POSTN is an important factor of LUAD prognosis.
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Gao et al. (2022) conducted an observational in Lung adenocarcinoma (LUAD). Elevated POSTN expression and decreased B-cell infiltration vs. Normal tissues was evaluated on Overall survival, disease-free survival, and progression-free interval. Elevated POSTN expression and decreased B-cell infiltration were identified as prognostic factors for lung adenocarcinoma, with a 1-year negative predictive value for overall survival of 0.902.
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