Key result
Uterine artery pulsatility index at 11-14 weeks strongly predicts pre-eclampsia with ~0.95 AUC.
Why the study?
Pre-eclampsia complicates 2% of pregnancies and early prediction using maternal echocardiography and uterine artery pulsatility index is needed to identify high-risk nulliparous women.
Do maternal echocardiography and uterine artery Doppler at 11-14 weeks predict the development of pre-eclampsia in healthy nulliparous women?
Population
135 healthy nulliparous women at 11-14 weeks gestation
Comparison
Maternal echocardiography and uterine artery Doppler assessment
Design
Prospective observational cohort study
Follow-up
Up to 36 weeks gestation
Authors
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UAPI at 11-14 weeks may support early PE risk identification in nulliparas; leaves open whether echocardiography adds value beyond Doppler.
Cohort (n=135)
No
Do maternal echocardiography and uterine artery Doppler at 11-14 weeks predict the development of pre-eclampsia in healthy nulliparous women?
Effect estimate: AUC 0.945 (95% CI 0.860-1.00)
Uterine artery pulsatility index and total peripheral resistance measured in the first trimester can help predict the development of pre-eclampsia in nulliparous women.
Sah et al. (2021) conducted a cohort in Pre-eclampsia (n=135). Uterine artery pulsatility index and maternal echocardiography vs. Normal pregnancy was evaluated on Prediction of pre-eclampsia (AUC 0.945, 95% CI 0.860-1.00). Uterine artery pulsatility index measured at 11-14 weeks of gestation was the best predictor for the development of pre-eclampsia, demonstrating an area under the curve of 0.945.
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