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May 13, 2008Cytogenetics and Cell Genetics

Mapping studies and expression of genes located on human chromosome 11, band q23

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Authors

PSPaul SavageMcGill UniversityCJCarol JonesFukushima Medical UniversityJSJack SilverTeledyne Technologies (United States)

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Implication

In vitro cytogenetic analysis reveals gene order along chromosome 11q23 in leukemic cells, suggesting candidate genes do not directly cause translocation malignancy.

Key Points

  • Determine whether candidate proto-oncogenes located at chromosome band 11q23 are directly disrupted by a reciprocal translocation and map their spatial arrangement.
  • Examined a human leukemic cell line containing a reciprocal translocation involving band 11q23 and derived somatic cell hybrids.
  • Assayed five specific genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1 for direct involvement and regional location.
  • Demonstrated that NCAM, CD3D, CD3E, THY1, and ETS1 undergo no direct disruption or structural rearrangement in this leukemia.
  • Constructed a partial regional genetic map defined as 11cen--NCAM--CD3([G, D], E)--parallel--(ETS1, THY1)--11qter.

Cite This Study

Savage et al. (2008) studied this question.

synapsesocial.com/papers/6aaf38e8a035123a3ef167d5https://doi.org/10.1159/000132680
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints2008 · 30 citations
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  3. 3A second nonrandom translocation, der(16)t(1;16)(q21;q13), in Ewing sarcoma and peripheral neuroectodermal tumor2008 · 82 citations
  4. 4The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias1988 · 863 citations
  5. 5Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences risk of acute myeloid leukemia.2026