Key result
High baseline D-dimer is not linked to recurrent VTE but is associated with more composite events.
Why the study?
Elevated D-dimer concentration may be a useful prognostic predictor for patients with venous thromboembolism, but its relationship with clinical outcomes in Japanese patients was unclear.
Does high baseline D-dimer concentration predict worse clinical outcomes in Japanese patients with venous thromboembolism?
Population
949 Japanese patients with venous thromboembolism, mean age 68 years, 40.7% male
Comparison
High baseline D-dimer concentration (≥7.6 μg/ml) vs low baseline D-dimer concentration (<7.6 μg/ml)
Design
Prospective multicenter cohort study
Authors
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High D-dimer linked to higher composite events in VTE; leaves open its utility for risk stratification or therapy guidance.
Cohort (n=949)
Yes
Does high baseline D-dimer concentration predict worse clinical outcomes in Japanese patients with venous thromboembolism?
Hazard Ratio: 1.09 (95% CI 0.59–2.01)
Absolute Event Rate: 2.8% vs 2.5%
p-value: p=0.788
Elevated baseline D-dimer (≥7.6 μg/ml) is associated with a significantly higher risk of composite adverse clinical events in Japanese patients with venous thromboembolism.
Migita et al. (2023) conducted a cohort in Venous thromboembolism (n=949). High baseline D-dimer concentration (≥7.6 μg/ml) vs. Low baseline D-dimer concentration (<7.6 μg/ml) was evaluated on Recurrence or aggravation of symptomatic VTE (HR 1.09, 95% CI 0.59-2.01, p=0.788). High baseline D-dimer concentration (≥7.6 μg/ml) did not significantly increase the risk of recurrent or worsening symptomatic VTE compared to low D-dimer concentration (HR 1.09), though it was associated with a higher rate of composite clinically relevant events.
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