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June 29, 2026Thrombosis JournalOpen Access

Association between D-dimer difference and risk of postoperative venous thromboembolism in endometrial cancer: a retrospective cohort study

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Authors

WLWeipeng LiHZHui ZhengLZLan Zhen

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Overview

Retrospective cohort study investigates D-dimer changes and VTE risk in endometrial cancer patients, indicating potential for monitoring in clinical settings.

Key Points

  • This study examines how changes in D-dimer levels relate to the risk of venous thromboembolism in endometrial cancer patients post-surgery.
  • Retrospective cohort design involving 307 endometrial cancer patients who underwent surgery.
  • Follow-up period until December 2025 with multivariable logistic regression for analysis.
  • Investigation of threshold effects and variable changes in VTE risk based on D-dimer levels.
  • Each one-unit increase in D-dimer change was associated with a higher VTE risk (adjusted OR = 1.202; 95% CI: 1.076–1.342; P = 0.001).
  • A significant threshold effect was found at D-dimer level of 3.78, where VTE risk increased sharply below this threshold (OR = 7.761; 95% CI: 4.286–14.051).
  • Above the threshold, the risk declined (OR = 0.643; 95% CI: 0.526–0.785).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a420b2ff91bb43ea919254fhttps://doi.org/10.1186/s12959-026-00893-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations2026
  2. 2Early detection of thrombosis after cesarean section using changes in D-dimer levels2014 · 2 citations
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  4. 4Dynamics of D‐dimer in non‐small cell lung cancer patients receiving radical surgery and its association with postoperative venous thromboembolism2020 · 19 citations
  5. 5Relationship between baseline D-dimer and prognosis in Japanese patients with venous thromboembolism: Insights from the J’xactly study2023 · 2 citations