Key result
Rotavirus accounts for ~38% of pediatric acute diarrhea hospitalizations, predominantly G1P[8] and G2P[4] strains.
Why the study?
Rotavirus infection is a common cause of severe diarrhea and hospital admissions among under-five children, but local burden and strain prevalence data are needed.
What is the burden and prevalent strains of rotavirus diarrhea among under-five children admitted with acute diarrhea in southern Karnataka, India?
Observational (n=95)
Yes
What is the burden and prevalent strains of rotavirus diarrhea among under-five children admitted with acute diarrhea in southern Karnataka, India?
Rotavirus accounts for a considerable proportion (38.3%) of acute diarrhea admissions among under-five children in southern Karnataka, India.
Rotavirus positivity reached 38% among under-five diarrhea admissions; leaves open questions on post-vaccine strain dynamics in this setting.
Background Rotavirus infection is the common cause of severe diarrhea among under-five children. Globally it is responsible for majority of the hospital visits and admissions due to diarrhea in this age group. This hospital-based surveillance aimed to assess the burden of rotavirus diarrhea and to identify its prevalent strains among under-five children. Methods The study was conducted in two secondary level health care facilities of Manipal University, Manipal during November 2011 through July 2012. All under-five children admitted with acute diarrhea were recruited into the study. Results A total of 95 children were admitted with acute diarrhea during the study period. Of the 95 stool samples collected, 14 were inadequate and 81 samples were tested for the presence of rotavirus using commercial enzyme immunoassay kit (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were shipped to Central laboratory at CMC, Vellore for strain surveillance and characterization. Out of the 81 stool samples tested for rotavirus, 31 samples (38.3%) were positive for rotavirus VP6 antigen. Rota positivity was observed to be highest during the month of December (29.0%) and lowest in the month of June. Majority of the rotavirus positive cases (45.2%) were among children aged 13–24 months and among those who had very severe diarrhea (56.5%). The most common genotypes identified were G1P[8] and G2P[4] strains (25.8% each). Conclusions Though the burden of overall diarrhea among under-five children is not very high in this area, the proportion of rotavirus diarrhea among the hospitalized children is considerably high.
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Shetty et al. (2016) conducted an observational in Acute diarrhea (n=95). Rotavirus infection was evaluated on Rotavirus positivity in stool samples. Among under-five children hospitalized with acute diarrhea, 38.3% of tested stool samples were positive for rotavirus, with G1P[8] and G2P[4] being the most common genotypes.
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