Key result
DLGAP5-PINK1 and BUB1B-PINK1 expression predicts adult adrenocortical tumor survival with marginal pediatric effect.
Why the study?
The prognostic and molecular heterogeneity of adrenocortical tumors necessitates validation of combined BUB1B, DLGAP5, and PINK1 gene expression as outcome predictors in other cohorts.
Does the combined expression of BUB1B, DLGAP5, and PINK1 predict disease-free and overall survival in patients with adrenocortical tumors?
Cohort (n=52)
Does the combined expression of BUB1B, DLGAP5, and PINK1 predict disease-free and overall survival in patients with adrenocortical tumors?
The combined expression of BUB1B, DLGAP5, and PINK1 genes is a strong prognostic predictor in adult, but not pediatric, adrenocortical tumors.
May refine adult adrenocortical tumor prognostication; leaves open pediatric utility and requires prospective validation.
BACKGROUND: A recent microarray study identified a set of genes whose combined expression patterns were predictive of poor outcome in a cohort of adult adrenocortical tumors (ACTs). The difference between the expression values measured by qRT-PCR of DLGAP5 and PINK1 genes was the best molecular predictor of recurrence and malignancy. Among the adrenocortical carcinomas, the combined expression of BUB1B and PINK1 genes was the most reliable predictor of overall survival. The prognostic and molecular heterogeneity of ACTs raises the need to study the applicability of these molecular markers in other cohorts. OBJECTIVE: To validate the combined expression of BUB1B, DLGAP5, and PINK1 as outcome predictor in ACTs from a Brazilian cohort of adult and pediatric patients. PATIENTS AND METHODS: BUB1B, DLGAP5, and PINK1 expression was assessed by quantitative PCR in 53 ACTs from 52 patients - 24 pediatric and 28 adults (one pediatric patient presented a bilateral asynchronous ACT). RESULTS: DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT. In the pediatric cohort, these molecular predictors were only marginally associated with disease-free survival but not with overall survival. CONCLUSION: This study confirms the prognostic value of the combined expression of BUB1B, DLGAP5, and PINK1 genes in a Brazilian group of adult ACTs. Among pediatric ACTs, other molecular predictors of outcome are required.
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Fragoso et al. (2011) conducted a cohort in Adrenocortical tumors (n=52). Combined expression of BUB1B, DLGAP5, and PINK1 was evaluated on Disease-free survival and overall survival. Combined expression of DLGAP5-PINK1 and BUB1B-PINK1 strongly predicted disease-free and overall survival in adult adrenocortical tumors, but were only marginally associated in pediatric patients.
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