Key result
Knockdown of Bdnf in the nucleus of the solitary tract significantly increased lean mass and energy intake in middle-aged mice despite lower physical activity.
Why the study?
The specific brain region where brain-derived neurotrophic factor (Bdnf) influences appetite and body weight has not been fully defined.
Answers are grounded in this paper and cite their sources.
Ageing is commonly accompanied by loss muscle mass a concomitant increase in adiposity, which increases the risk of obesity. The nucleus of the solitary tract (NTS) is a brain region located in the medulla oblongata of the brainstem and has been recognized as an important modulator of homeostasis, including energy homeostasis Brain-derived neurotrophic factor (Bdnf) is a key regulator of energy balance. Both people and mice that do not produce Bdnf or a key receptor that it signals through are hyperphagic and obese. However, where Bdnf is produced to influence appetite and body weight has not been fully defined. One of the regions where Bdnf is expressed is the NTS
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Arčon et al. (2022) studied Obesity and energy homeostasis (animal model) (n=16). Bdnf knockdown in the NTS (AAV-Cre-mCherry) vs. Control AAV-mCherry was evaluated on Lean mass (95% CI 1.201 to 5.124, p=0.0040). Knockdown of Bdnf in the nucleus of the solitary tract significantly increased lean mass and energy intake in middle-aged mice despite lower physical activity.
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