Key result
COVID-19 vaccine myocarditis in males is linked to higher LVEF and less LGE vs other causes.
Why the study?
Differences in cardiac MRI findings between COVID-19 mRNA vaccine-associated myocarditis and acute myocarditis from other causes were not well characterized.
Does COVID-19 mRNA vaccine-associated myocarditis present with different cardiovascular magnetic resonance findings compared to acute myocarditis from other causes in male patients?
Observational (n=28)
Does COVID-19 mRNA vaccine-associated myocarditis present with different cardiovascular magnetic resonance findings compared to acute myocarditis from other causes in male patients?
COVID-19 vaccine-associated myocarditis in males appears to have a milder imaging phenotype on cardiovascular magnetic resonance compared to acute myocarditis from other causes.
Suggests milder CMR phenotype in vaccine-associated myocarditis; leaves open prognostic value and need for outcome studies.
By comparing phenotypic clinical characteristics and cardiovascular magnetic resonance (CMR) findings in 14 patients with COVID-19 mRNA vaccine-associated myocarditis to 14 patients with acute myocarditis from other causes, we found that patients with COVID-19 vaccination- associated acute myocarditis have higher left ventricular ejection fraction, higher left ventricular global circumferential and radial strain, and less involvement of late gadolinium enhancement in the septal segments with less involvement of midmyocardial pattern of late gadolinium enhancement, compared to patients with acute myocarditis from other causes.
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Patel et al. (2022) conducted an observational in Acute myocarditis (n=28). COVID-19 mRNA vaccination vs. Acute myocarditis from other causes was evaluated on Cardiovascular magnetic resonance (CMR) findings including LVEF, strain, and late gadolinium enhancement. COVID-19 mRNA vaccine-associated acute myocarditis in males was associated with higher LVEF, higher strain, and less septal late gadolinium enhancement compared to myocarditis from other causes.
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