Key result
Monozygotic twins with CAD display strikingly similar clinical courses and disease distributions linked to identical heredity.
Why the study?
The contribution of heredity as an independent risk factor for coronary artery disease compared to other major risk factors remains difficult to distinguish.
Population
Two pairs of monozygotic twins with coronary artery disease
Comparison
Within twin pairs comparison of clinical course and coronary artery disease distribution
Design
Case report
Authors
Loading...
Should not yet alter CAD management; supports heritability hypotheses but remains hypothesis-generating.
Case Report (n=4)
Monozygotic twins with coronary artery disease show striking similarities in disease distribution and clinical course, highlighting the potential role of heredity.
Holmes et al. (1981) conducted a case report in Coronary artery disease (n=4). Monozygotic twin status (heredity) was evaluated on Similarities in clinical course, response to exercise, and distribution of coronary artery disease. Monozygotic twins with coronary artery disease demonstrated striking similarities in clinical course, response to exercise, and disease distribution, likely explained by identical heredity.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: