Key result
Cold stimulus drives a greater increase in uterine artery pulsatility index in preeclampsia versus normal controls.
Why the study?
The effect of cold stimulus on uterine artery blood flow velocity waveforms in late pregnant women with and without preeclampsia was investigated to understand vascular responses.
Does cold stimulus alter uterine artery blood flow in late pregnant women with and without preeclampsia?
Does cold stimulus alter uterine artery blood flow in late pregnant women with and without preeclampsia?
Cold stimulus induces constriction of the uterine artery and decreases placental blood flow, significantly increasing the pulsatility index in both preeclamptic and normal pregnant women.
Exaggerated uterine artery PI rise with cold in preeclampsia may signal abnormal vasoreactivity; leaves open whether cold pressor Doppler aids risk stratification.
Cold stimulus, immersing the hand into ice water, was given to pregnant women with and without preeclampsia. The uterine artery blood flow was observed before, during and after the stimulus by Doppler ultrasound. The pulsatility index in the uterine artery blood flow was significantly increased by the cold exposure in preeclampsia from 1.14 to 1.52, whereas it increased in normal control from 0.95 to 1.25. In two of 11 cases of preeclampsia with fetal growth restriction, cold stimulus to the mother elicited a decrease of variability on fetal heart rate monitoring. Cold stimulus induces the constriction of the uterine artery, leading to a decrease of placental blood flow.
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Kimura et al. (1998) studied Preeclampsia in late pregnancy. Cold stimulus (immersing hand into ice water) vs. Normal pregnant controls was evaluated on Pulsatility index in the uterine artery blood flow. Cold stimulus significantly increased the pulsatility index in uterine artery blood flow from 1.14 to 1.52 in women with preeclampsia, compared to an increase from 0.95 to 1.25 in normal controls.
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