Key result
Bariatric surgery is linked to a ~35% increase in supraclavicular brown fat fractional uptake rate.
Why the study?
The effect of bariatric surgery-induced weight loss on lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women was not well understood.
Does bariatric surgery-induced weight loss improve lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women?
Population
Morbidly obese women and non-obese controls
Comparison
Pre-surgery baseline vs post-bariatric surgery-induced weight loss
Design
Observational study using F-FTHA-PET and CT imaging
Authors
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May link bariatric surgery to enhanced brown fat activity in obese women; hypothesis-generating and should not yet change practice.
Observational
Does bariatric surgery-induced weight loss improve lipid metabolism in supraclavicular brown adipose tissue in morbidly obese women?
Absolute Event Rate: 0.0074% vs 0.0055%
p-value: p=.01
Bariatric surgery-induced weight loss in morbidly obese women improves brown adipose tissue lipid metabolism and decreases triglyceride content, which correlates with improved whole-body insulin sensitivity.
Dadson et al. (2018) conducted an observational in Morbid obesity. Bariatric surgery vs. Pre-surgery baseline and healthy controls was evaluated on Supraclavicular fractional uptake rate (FUR) (p=.01). Bariatric surgery in morbidly obese women increased supraclavicular fractional uptake rate from 0.0055 to 0.0074 1/min (P=0.01) and improved brown fat proportion.
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