Key result
Obesity is linked to worse performance on non-invasive autonomic function tests versus age-matched controls.
Why the study?
Obesity is associated with autonomic dysfunction, but the extent of underlying autonomic neuropathy in obese subjects compared to age-matched controls needed assessment.
Is obesity associated with impaired autonomic function in young adults compared to age-matched controls?
Case-Control (n=30)
Is obesity associated with impaired autonomic function in young adults compared to age-matched controls?
p-value: p=<0.05
Obesity in young adults is associated with latent autonomic neuropathy, suggesting a potential need for early screening to prevent future cardiovascular complications.
May indicate latent neuropathy in obese young adults; hypothesis-generating and should not yet change practice.
Obesity is one of the common significant health hazards and is associated with autonomic dysfunction. The present study was designed to assess the underlying autonomic neuropathy in obese subjects and to compare it with age-matched controls. Thirty obese subjects in the age group of 21–40 years were recruited for the study. Six non-invasive autonomic function tests were performed out of which four were based mainly on parasympathetic control (Heart rate response to standing (30:15 ratio), The S:L (standing to lying) ratio, The Valsalva ratio, Heart rate response to deep breathing) and the other two were mainly sympathetic (Isometric Handgrip Exercise Test and Cold Pressor Test). Results were analysed by ANOVA with SPSS version 17.0 using unpaired ‘t’ test. Results showed that Heart rate response to standing (30:15 ratio), The S:L (standing to lying) ratio, The Valsalva ratio, Heart rate response to deep breathing, Isometric Handgrip Exercise Test and Cold Pressor Test were significantly lower (p <0.05) in obese subjects as compared to control subjects. Conclusions: Latent autonomic neuropathy may be present in otherwise healthy obese individuals. Early and regular screening of obese individuals is necessary to prevent any future complications.
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Garg et al. (2013) conducted a case-control in Obesity (n=30). Obesity vs. Age-matched controls was evaluated on Six non-invasive autonomic function tests (parasympathetic and sympathetic) (p=<0.05). Obesity was associated with significantly lower performance on six non-invasive autonomic function tests compared to age-matched controls (p<0.05).
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