Key result
Surgical resection of the first reported gallbladder dedifferentiated liposarcoma achieves 8-month disease-free survival.
Why the study?
Liposarcoma of the gallbladder is an extremely rare sarcoma with only five cases previously reported in the literature.
Case Report (n=1)
No
This is the first reported case of dedifferentiated liposarcoma of the gallbladder.
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Adds sixth gallbladder liposarcoma case; extends sparse reports but leaves management questions open.
BACKGROUND: Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge. CASE PRESENTATION: A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. The CT report suggested gallbladder liposarcoma. A cholecystectomy associated with resection of segments IV-B and V of the liver were performed. Intraoperative frozen sections were compatible with gallbladder sarcoma. Anatomopathological examination and immunohistochemistry confirmed dedifferentiated liposarcoma with foci of heterologous leiomyosarcomatous differentiation and undifferentiated fusocellular areas of high histological grade. CONCLUSION: This is the first case of dedifferentiated liposarcoma of the gallbladder to be reported.
Costa et al. (2018) conducted a case report in Dedifferentiated liposarcoma of the gallbladder (n=1). Cholecystectomy and liver resection was evaluated on Disease recurrence or metastasis. A 71-year-old woman with the first reported case of dedifferentiated liposarcoma of the gallbladder underwent surgical resection and remained free of disease at 8 months.
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