Liposarcoma represents the most frequently encountered soft tissue sarcoma, comprising approximately 15-20% of all malignant tumors of mesenchymal origin. This neoplasm most frequently arises in the extremities and retroperitoneal space, while visceral involvement is considered uncommon. Gastric liposarcoma is an exceedingly rare condition with limited documentation in the literature. We present a case of well-differentiated gastric liposarcoma in a 63-year-old female patient. The primary aim of this report is to share our clinical experience with this rare entity, while the secondary aim is to evaluate the diagnostic challenges and surgical management strategies based on a literature review. A 63-year-old female patient was admitted to our hospital with complaints of epigastric pain and decreased oral intake persisting for approximately 6 months. Computed tomography revealed a 107 × 55 × 65 mm fat-density lesion compatible with lipoma in the antropyloric region of the stomach, which significantly occupied and narrowed the gastric lumen. Subtotal gastrectomy with Roux-en-Y anastomosis was performed on the patient. Histopathological examination revealed well-differentiated liposarcoma. The postoperative period was uneventful. Postoperative treatment was determined by a multidisciplinary surgical-oncology council, and active surveillance was preferred. Endoscopic and radiological follow-up was planned for the patient after discharge. The patient remained recurrence-free during the 26-month follow-up period. This report highlights the diagnostic challenges of gastric liposarcoma and the need for standardized follow-up.
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