Key result
APOB ins/ins genotype linked to ~44% higher postprandial TAG AUC versus del/del.
Why the study?
Previous studies on the association between the APOB ins/del polymorphism and postprandial lipaemia were inconsistent, underpowered, male-focused, or had limited postprandial characterization.
Does the APOB ins/del polymorphism influence postprandial lipaemia and insulin responses to dietary fat intake in healthy adults?
Observational (n=147)
No
Does the APOB ins/del polymorphism influence postprandial lipaemia and insulin responses to dietary fat intake in healthy adults?
The APOB ins/del polymorphism is a significant genetic determinant of inter-individual variability in postprandial triglycerides and insulin following dietary fat intake.
APOB ins/del genotype was associated with postprandial TAG responses; leaves open replication and clinical relevance in larger, at-risk cohorts.
BACKGROUND: Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty acids, glucose and insulin levels in healthy adults. FINDINGS: Healthy participants (n = 147) consumed a standard test breakfast (0 min; 49 g fat) and lunch (330 min; 29 g fat), with blood samples collected before (fasting) and on 11 subsequent occasions until 480 min after the test breakfast. The ins/ins homozygotes had higher fasting total cholesterol, LDL-cholesterol, TAG, insulin and HOMA-IR and lower HDL-cholesterol than del/del homozygotes (P < 0.017). A higher area under the time response curve (AUC) was evident for the postprandial TAG (P < 0.001) and insulin (P = 0.032) responses in the ins/ins homozygotes relative to the del/del homozygotes, where the genotype explained 35% and 7% of the variation in the TAG and insulin AUCs, respectively. CONCLUSIONS: In summary, our findings indicate that the APOB ins/del polymorphism is likely to be an important genetic determinant of the large inter-individual variability in the postprandial TAG and insulin responses to dietary fat intake.
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Vimaleswaran et al. (2015) conducted an observational in Healthy adults (n=147). APOB insertion/deletion polymorphism (rs17240441) vs. del/del homozygotes was evaluated on Postprandial triacylglycerol (TAG) area under the curve (AUC) (44% higher TAG AUC, p=<0.001). The APOB ins/ins genotype was associated with a 44% higher postprandial triacylglycerol area under the curve compared to the del/del genotype following sequential meal ingestion.
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