February 1, 2004Journal of Molecular EndocrinologyOpen Access

Postprandial lipemia is modified by the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus

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Why the study?

Does the SR-BI exon 1 polymorphism modify postprandial lipemia after a fat-rich meal in normolipidemic volunteers?

Structured PICO

Does the SR-BI exon 1 polymorphism modify postprandial lipemia after a fat-rich meal in normolipidemic volunteers?

Population

47 normolipidemic volunteers who were homozygous for the E3 allele at the APOE gene (37 homozygous for the common genotype (1/1) at the SR-BI exon 1 polymorphism and 10 heterozygous (1/2))

Intervention

Fat-rich meal containing 1 g fat and 7 mg cholesterol per kg body weight and vitamin A 60,000 IU/m2 body surface

Comparator

Comparison between SR-BI exon 1 polymorphism genotypes (1/1 vs 1/2)

Outcome

Postprandial responses for triacylglycerols and retinyl palmitate in small triacylglycerol-rich lipoproteins over 11 hourssurrogate

The presence of the heterozygous 1/2 genotype at the SR-BI exon 1 polymorphism is associated with a lower postprandial lipemic response compared to the 1/1 genotype.

Discussion

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Implication

SR-BI 1/2 genotype was associated with lower postprandial lipemia; hypothesis-generating and leaves clinical implications open pending larger studies.

Cite This Study

Pérez‐Martínez et al. (2004) studied this question.

synapsesocial.com/papers/6a75d30e92ba9b63c6161b3c https://doi.org/10.1677/jme.0.0320237

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Implication

SR-BI 1/2 genotype was associated with lower postprandial lipemia; hypothesis-generating and leaves clinical implications open pending larger studies.