Key result
After adjusting for fasting TAG, the apolipoprotein E4 phenotype was associated with the lowest postprandial TAG response relative to the E3/3 group (p<0.01).
Why the study?
Does apolipoprotein E polymorphism influence postprandial lipemia after a standardized fat meal in healthy men?
Observational (n=25)
Does apolipoprotein E polymorphism influence postprandial lipemia after a standardized fat meal in healthy men?
p-value: p=<0.01
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May aid in explaining variable postprandial responses; leaves open any role in clinical CVD risk assessment.
Brown et al. (1991) conducted an observational in Healthy (n=25). Apolipoprotein E4 phenotype vs. Apolipoprotein E2/3 or E3/3 phenotypes was evaluated on Postprandial plasma triacylglyceride (TAG) and chylomicron retinyl ester (RE) concentrations (p=<0.01). After adjusting for fasting TAG, the apolipoprotein E4 phenotype was associated with the lowest postprandial TAG response relative to the E3/3 group (p<0.01).
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