Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects.

14 normolipemic subjects homozygous for the apo E2 (n=4), apo E3 (n=5), or apo E4 (n=5) phenotype, selected from a coronary screening program with plasma cholesterol 5.0-6.2 mmol/liter.

Injection of radioiodinated VLDL1 and VLDL2 to trace apolipoprotein B metabolism

Comparison between apo E2, apo E3, and apo E4 homozygous phenotypes

Conversion of apolipoprotein B through intermediate density lipoprotein (IDL) to low density lipoprotein (LDL) and fractional catabolic ratessurrogate