Why the study?
How does apolipoprotein E deficiency affect the metabolism and kinetics of low-density lipoprotein?
How does apolipoprotein E deficiency affect the metabolism and kinetics of low-density lipoprotein?
ApoE is essential for the conversion of IDL to LDL, the formation of kinetically normal LDL, and the regulation of LDL receptor function.
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ApoE-deficient case illustrates LDL kinetic shifts; leaves open therapeutic targeting in type III hyperlipoproteinemia pending larger studies.
Gabelli et al. (1987) studied this question.
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