Key result
Cardiopulmonary bypass is linked to myeloid-derived suppressor cell accumulation in ~93% of patients, impairing T-cells.
Why the study?
Cardiopulmonary bypass is associated with a long-lasting immunosuppressive state that increases the risk of postoperative complications, but mechanisms of this immunosuppression are not fully elucidated.
Does cardiopulmonary bypass induce immunosuppression through the accumulation of myeloid-derived suppressor cells and arginine depletion in patients undergoing cardiac surgery?
Observational (n=71)
No
Does cardiopulmonary bypass induce immunosuppression through the accumulation of myeloid-derived suppressor cells and arginine depletion in patients undergoing cardiac surgery?
Cardiopulmonary bypass induces immunosuppression by triggering the accumulation of myeloid-derived suppressor cells that deplete serum arginine, suggesting L-arginine supplementation may counteract post-bypass immunoparalysis.
May contribute to postoperative immunosuppression after cardiac surgery; leaves open whether arginine repletion warrants testing.
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Hübner et al. (2019) conducted an observational in Cardiac surgery with cardiopulmonary bypass (n=71). Cardiopulmonary bypass vs. Pre-cardiopulmonary bypass baseline was evaluated on Expression of immunomodulatory cell markers and T cell effector functions. Cardiopulmonary bypass triggered the accumulation of myeloid-derived suppressor cells in 66 of 71 patients, impairing T cell effector functions by increasing serum arginine breakdown.
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