Key result
Tumor-associated tissue eosinophilia shows no correlation with prognostic parameters like tumor differentiation, invasion, or metastasis.
Why the study?
The prognostic role of tumor-associated tissue eosinophilia in oral squamous cell carcinoma was unclear and needed investigation.
Does tumor-associated tissue eosinophilia correlate with prognostic parameters in oral squamous cell carcinoma?
Observational (n=76)
Does tumor-associated tissue eosinophilia correlate with prognostic parameters in oral squamous cell carcinoma?
p-value: p=>0.05
Tumor-associated tissue eosinophilia does not appear to be a significant prognostic factor in oral squamous cell carcinoma.
Tumor-associated tissue eosinophilia should not guide prognosis in oral squamous cell carcinoma; leaves open its role in larger prospective cohorts.
Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.
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Andisheh‐Tadbir et al. (2009) conducted an observational in Oral Squamous Cell Carcinoma (n=76). Tumor-associated tissue eosinophilia (TATE) was evaluated on Correlation with prognostic parameters including tumor differentiation, invasion, and locoregional metastasis (p=>0.05). Tumor-associated tissue eosinophilia showed no statistically significant correlation with prognostic parameters such as tumor differentiation, invasion, or locoregional metastasis (P>0.05).
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