Key result
Intense tumor-associated tissue eosinophilia was significantly associated with advanced clinical stage and muscular infiltration in oral squamous cell carcinomas (P=0.009).
Why the study?
Is tumor-associated tissue eosinophilia associated with tissue invasion and prognosis in patients with oral squamous cell carcinoma?
Observational (n=43)
No
Is tumor-associated tissue eosinophilia associated with tissue invasion and prognosis in patients with oral squamous cell carcinoma?
p-value: p=0.009
Intense tumor-associated tissue eosinophilia reflects stromal invasion in advanced oral squamous cell carcinomas but does not predict long-term survival.
May mark stromal invasion in oral SCC; hypothesis-generating for prognosis, needs prospective validation.
This study investigated if tumor-associated tissue eosinophilia (TATE) could be associated with the process of tissue invasion in oral squamous cell carcinomas (OSCCs) and its influence on patient's prognosis. Forty-three patients treated for OSCCs with or without lymph nodes involvement, at A. C. Camargo Cancer Hospital, Brazil, were selected for TATE analysis. Two degrees of tissue eosinophilia were established in OSCC: absent/mild and intense. The TATE was evaluated in relation to the clinicopathological features and prognostic value using chi( 2) test and the Kaplan-Meier method. Most of the patients with OSCC in advanced clinical stage presented muscular infiltration and significantly intense TATE whereas those with tumors in early stage frequently showed absent/mild eosinophilia (P = .009). The TATE showed no prognostic value for 5-year and 10-year survival rates of the OSCC. These findings suggest that intense TATE seems to reflect the stromal invasion of the OSCCs that occur in advanced clinical stage.
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Oliveira et al. (2009) conducted an observational in Oral squamous cell carcinomas (n=43). Intense tumor-associated tissue eosinophilia (TATE) vs. Absent/mild eosinophilia was evaluated on Association with clinical stage and muscular infiltration (p=0.009). Intense tumor-associated tissue eosinophilia was significantly associated with advanced clinical stage and muscular infiltration in oral squamous cell carcinomas (P=0.009).
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