What question did this study set out to answer?

Identify bovine major histocompatibility complex (BoLA) class II polymorphisms and haplotypes associated with bovine leukemia virus (BLV) proviral load in Holstein cows.

May 16, 2019RetrovirologyOpen Access

Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan

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Authors

STShin‐nosuke TakeshimaJumonji University AOAyumu OhnoTokai University YAYoko AidaThe University of Tokyo

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Implication

Cross-sectional survey reveals BoLA-DRB3 polymorphisms correlate strongly with bovine leukemia virus proviral load in Holstein cows, suggesting viable genetic markers for disease control.

Key Points

Identify bovine major histocompatibility complex (BoLA) class II polymorphisms and haplotypes associated with bovine leukemia virus (BLV) proviral load in Holstein cows.
Assessed 1,290 cows from BLV-positive farms in a nationwide survey across Japan (2011–2014), evaluating 910 BLV-infected cows categorized into high proviral load (n=569) and low proviral load (n=341).
Analyzed the frequencies of BoLA-DRB3 alleles, BoLA-DQA1 alleles, and BoLA class II haplotypes to determine association strength using maximum odds ratios (OR).
BoLA-DRB3 exhibited the strongest association with BLV proviral load (OR 13.9), outperforming BoLA-DQA1 (OR 11.5) and BoLA class II haplotypes (OR 6.2).
Identified three resistant alleles associated with lower viral risk (BoLA-DRB3*002:01, *009:02, and *014:01; OR > 1) and two susceptible alleles linked to high proviral load (BoLA-DRB3*012:01 and *015:01; OR < 1).

Cite This Study

Takeshima et al. (2019) studied this question.

synapsesocial.com/papers/6aaf66ab7e8385fbd3d06615 https://doi.org/10.1186/s12977-019-0476-z

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Implication

Cross-sectional survey reveals BoLA-DRB3 polymorphisms correlate strongly with bovine leukemia virus proviral load in Holstein cows, suggesting viable genetic markers for disease control.

Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan

Discussion

Member takes

Implication

Key Points

Cite This Study

Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan

Discussion

Member takes

Implication

Key Points

Cite This Study

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