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August 22, 2025PathogensOpen Access

Polymorphism of BoLA-DRB3 in Semen and Its Influence on Progeny Derived from Semen with Resistance and Susceptibility to Bovine Leukemia Virus Proviral Load

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Authors

ABAronggaowa BaoSWSonoko WatanukiRMRyosuke Matsuura

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Overview

Investigation finds BLV proviral load higher in progeny from susceptible BoLA-DRB3 alleles in semen, indicating genetic influence.

Key Points

  • Progeny from semen with susceptible BoLA-DRB3 alleles had significantly higher proviral load.
  • Analysis of 178 semen samples identified 20 BoLA-DRB3 alleles, with DRB3*016:01 being the most common.
  • Study connects BoLA-DRB3 allele variations in semen to BLV susceptibility in offspring.
  • Findings suggest potential for using BoLA-DRB3 as a breeding marker to reduce BLV infection.

Cite This Study

Bao et al. (2025) studied this question.

synapsesocial.com/papers/68af5707ad7bf08b1eadd9cdhttps://doi.org/10.3390/pathogens14090837
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distribution and influence of single-nucleotide polymorphisms affecting bovine leukemia virus proviral load in semen and progeny derived from semen in Japanese Black cattle2026
  2. 2Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan2019 · 89 citations
  3. 3High-throughput detection of bovine leukocyte antigen (BoLA)-DRB3 alleles associated with resistance to bovine leukemia virus using a rapid allele-specific PCR assay2025
  4. 4Infection with bovine leukemia virus belonging to group A or B-1 contributes more strongly to the development of enzootic bovine leukosis in young cattle than the presence of bovine lymphocyte antigen-DRB3 susceptibility alleles2024 · 1 citations
  5. 5Detection of Bovine Leukemia Virus in Bone Marrow of Patients with B-Cell Precursor Acute Lymphoblastic Leukemia: A Case–Control Study2026