Key result
Baseline moderate-to-severe depression linked to ~43% lower odds of 1-year smoking abstinence.
Why the study?
Depression may make smoking cessation more difficult and cessation may affect depression symptoms, but these associations require further assessment.
Does baseline depression predict 1-year smoking abstinence, and does abstinence improve depression symptoms in patients attending a smoking cessation clinic?
Population
3,775 patients attending a smoking cessation clinic in the Czech Republic from 2008 to 2014
Comparison
Patients with baseline depression vs patients without baseline depression
Design
Observational study using routinely collected clinic data
Follow-up
1 year
Authors
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Baseline depression may identify patients at higher risk of cessation failure; leaves open whether integrated treatment improves abstinence in observational cohorts.
Observational (n=3,775)
No
Does baseline depression predict 1-year smoking abstinence, and does abstinence improve depression symptoms in patients attending a smoking cessation clinic?
Odds Ratio: 0.57 (95% CI 0.45–0.74)
Absolute Event Rate: 25.8% vs 40.5%
p-value: p=< 0.001
Baseline depression reduces the likelihood of successful smoking cessation, but patients who successfully quit experience significant improvements in depressive symptoms.
Štěpánková et al. (2016) conducted an observational in Smoking and Depression (n=3,775). Baseline depression (moderate/severe) vs. No depression was evaluated on 1-year biochemically verified abstinence (OR 0.57, 95% CI 0.45 to 0.74, p=< 0.001). Baseline moderate/severe depression was associated with reduced 1-year smoking abstinence compared to no depression (25.8% vs 40.5%; OR 0.57, 95% CI 0.45-0.74, p<0.001).
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