Key result
G-CSF is linked to better cardiac function and lower post-MI mortality via stem cell mobilization.
Why the study?
The inflammatory reaction and cytokine cascade activation in myocardial infarction contribute to cardiac dysfunction and remodeling, and the potential of G-CSF as a novel therapy for MI requires further elucidation.
Cytokine-mediated regeneration therapy, particularly with G-CSF, represents a potential novel therapeutic strategy for improving cardiac function after myocardial infarction.
Many cytokines have been reported to be increased in human and animal models with cardiovascular diseases. Myocardial infarction (MI) is accompanied with an inflammatory reaction which induces cardiac dysfunction and remodeling. The inflammatory reaction has been investigated in animal models of MI or myocardial ischemia-reperfusion injury. The mechanisms by which cytokine cascade is activated in the infarcted myocardium have been recently elucidated. Several hematopoietic growth factors including interleukin-3 (IL-3), IL-6, granulocyte-macrophage colony-stimulating factors (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and stem cell factor (SCF) have been reported to be positive regulators of granulopoiesis and act at different stages of myeloid cell development. G-CSF plays a critical role in regulation of proliferation, differentiation, and survival of myeloid progenitor cells. G-CSF also causes a marked increase in the release of hematopoietic stem cells (HSCs) into the peripheral blood circulation, a process termed mobilization. Although cardiac myocytes have been considered as terminally differentiated cells, it has been recently reported that there are many proliferating cardiac myocytes after MI in human heart. After it was demonstrated that bone marrow stem cells (BMSCs) can differentiate into cardiac myocytes, myocardial regeneration has been widely investigated. Recently, G-CSF has been reported to improve cardiac function and reduces mortality after acute MI. Although the mechanism by which G-CSF ameliorates cardiac dysfunction is not fully understood, there is the possibility that G-CSF may regenerate cardiac myocytes and blood vessels through mobilization of BMSCs. In the future, cytokine-mediated regeneration therapy may become to be a novel therapeutic strategy for MI.
No takes yet. Share an insight, caveat, or question.
Takano et al. (2003) conducted a review in Acute Myocardial Infarction. G-CSF was evaluated. G-CSF has been reported to improve cardiac function and reduce mortality after acute myocardial infarction, potentially through the mobilization of bone marrow stem cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: