Key result
Granulocyte colony-stimulating factor (G-CSF) may offer cardioprotective effects in acute myocardial infarction by directly inhibiting apoptosis in injured myocardium.
This review highlights the potential cardioprotective effects of G-CSF in acute myocardial infarction, suggesting its benefits may stem from apoptosis inhibition rather than stem cell differentiation.
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G-CSF should not change AMI practice; hypothesis-generating for apoptosis inhibition and requires randomized confirmation.
Experimental data suggest that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) may have potential as a novel regenerative strategy in the setting of acute myocardial infarction (AMI). Potentially beneficial effects of G-CSF may be attributed mainly to direct action of the cytokine G-CSF on injured myocardium by inhibition of apoptosis, rather than to differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews potential cardioprotective effects of G-CSF and discusses experimental and clinical findings with G-CSF in the setting of AMI.
İnce et al. (2006) conducted a review in acute myocardial infarction (AMI). granulocyte colony-stimulating factor (G-CSF) was evaluated. Granulocyte colony-stimulating factor (G-CSF) may offer cardioprotective effects in acute myocardial infarction by directly inhibiting apoptosis in injured myocardium.
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