Why the study?
Diabetes mellitus is a major independent risk factor for cardiovascular diseases, and haemorheological parameters were evaluated as possible risk factors in type 2 diabetics.
Are haemorheological parameters altered in type 2 diabetic patients compared to healthy controls, potentially increasing cardiovascular risk?
Case-Control (n=150)
Are haemorheological parameters altered in type 2 diabetic patients compared to healthy controls, potentially increasing cardiovascular risk?
p-value: p=<0.05
Hypertensive type 2 diabetic patients exhibit elevated fibrinogen and ESR, suggesting an altered haemorheological profile that may contribute to increased cardiovascular risk.
Background: Diabetes mellitus is a syndrome with multiple aetiology characterized by chronic hyperglycaemia consequent on defects of insulin secretion, insulin action or both. Long term complications of chronic hyperglycaemia arise from underlying microvascular and macrovascular diseases.Objective: Diabetes mellitus is a major independent risk factor for cardiovascular diseases with diabetic subjects known to be at increased risk of cardiovascular diseases when compared with non-diabetic counterparts. Haemorheological parameters were thus evaluated in type 2 diabetics as possible risk factors for cardiovascular diseases.Method: One hundred patients with type 2 diabetes mellitus (78 normotensive, 22 hypertensives) were evaluated along with fifty apparently healthy age matched non-diabetic people serving as controls. Fasting blood glucose (FBG), Fibrinogen level (Fib), platelet count (PC), packed cell volume (PCV), plasma viscosity (PV), whole blood viscosity (WBV), white blood cells (WBC), and erythrocyte sedimentation rate (ESR) were determined using conventional methods.Results: FBG, ESR and Fib were significantly higher in the hypertensive diabetics (126.9±22.3mg/dl, 37.15±22.01mm/hr, and 3.75±1.09g respectively) compared with healthy non-diabetic controls, (83.9±11.5mg/dl, 8.50±4.75mmhr and 2.09±0.286g respectively (P<0.05). There were no significant differences in other measured parameters of normotensive and hypertensive diabetics though plasma viscosity (PV), showed slight but non-significant increase in diabetics with hypertension when compared with non-diabetic controls.Conclusion: We conclude that elevated blood glucose level results in increased level of fibrinogen and ESR in hypertensive T2DM with possible increased risk of other cardiovascular diseases.
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Odusan et al. (2013) conducted a case-control in Type 2 diabetes mellitus (n=150). Type 2 diabetes mellitus with hypertension vs. Healthy non-diabetic controls was evaluated on Haemorheological parameters including fasting blood glucose, erythrocyte sedimentation rate, and fibrinogen level (p=<0.05).
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