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Summarize emerging methodologies and clinical applications of high-throughput RNA sequencing in cancer research and tumor biology.

November 14, 2023Frontiers in GeneticsOpen Access

Editorial: Applications of RNA-seq in cancer and tumor research

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Editorial review highlights advances in transcriptomic profiling across multiple cancers, indicating broad potential for targeted oncology therapies.

Summarize emerging methodologies and clinical applications of high-throughput RNA sequencing in cancer research and tumor biology.
Synthesized findings from an 11-paper research collection exploring whole-transcriptome sequencing across diverse tumor types, including non-small cell lung cancer.
Evaluated applications of next-generation sequencing and long-read nanopore sequencing for single-cell gene expression, RNA structure, and spatial transcriptomics.
RNA sequencing enabled high-resolution whole-transcriptome profiling of differential gene expression and mRNA splicing isoforms distinguishing tumor from healthy tissue.
Nanopore long-read platforms accurately resolved full-length transcript isoforms in leukemias, breast, ovarian, and lung cancers to track disease mechanisms and treatment responses.

Lang et al. (2023) studied this question.

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Editorial review highlights advances in transcriptomic profiling across multiple cancers, indicating broad potential for targeted oncology therapies.