The pharmacological management of obesity in Prader-Willi syndrome: what does the future hold?

Graziano Grugni; Alessandro Sartorio; Antonino Crinò; Danilo Fintini

doi:10.1080/14656566.2026.2655969

March 24, 2026Expert Opinion on PharmacotherapyOpen Access

The pharmacological management of obesity in Prader-Willi syndrome: what does the future hold?

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Key Points

To review the underlying genetic and pathophysiological mechanisms of Prader-Willi syndrome and examine current and future pharmacological strategies for obesity management.
Narrative review synthesizing genetic mechanisms involving chromosome 15q11.2-13 and hypothalamic pathways in Prader-Willi syndrome.
Evaluation of clinical and preclinical evidence for existing weight-control strategies and emerging pharmacotherapies.
Pathogenesis is driven by the absence of paternal gene expression on chromosome 15, resulting in hypothalamic dysfunction and severe hyperphagia.
Conventional obesity medications offer limited efficacy, necessitating therapies specifically targeting central neuroendocrine appetite and satiety pathways.

Implication

Review evaluates emerging pharmacological approaches for obesity in Prader-Willi syndrome, highlighting novel therapeutic targets for appetite control.

Abstract

Prader-Willi syndrome (PWS) is a complex multisystem disorder, resulting from the lack of expression of paternally inherited imprinted genes on chromosome 15 (15q11.2-13). Three main genetic mec...

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Cite This Study

Grugni et al. (2026) studied this question.

synapsesocial.com/papers/6aaf6d1839233c92dd25ddf5 https://doi.org/10.1080/14656566.2026.2655969

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The pharmacological management of obesity in Prader-Willi syndrome: what does the future hold?

Key Points

Implication

Abstract

Discussion

Cite This Study

The pharmacological management of obesity in Prader-Willi syndrome: what does the future hold?

Key Points

Implication

Abstract

Discussion

Cite This Study

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