Key result
Vitamin replacement therapy shows no benefit in a case of Marchiafava-Bignami disease with spinal involvement.
Why the study?
Marchiafava-Bignami disease is a rare disorder with unknown etiology, typically associated with alcoholism and malnutrition, but spinal involvement is not well characterized.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Reports a rare case of Marchiafava-Bignami disease with spinal involvement in a non-alcoholic patient.
Marchiafava-Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Complex B deficiency was addressed. Magnetic resonance imaging (MRI) showed typical corpus callosum lesions. The clinical features and radiologic images suggested spinal cord involvement. Brain histopathologic findings were consistent with MBD. Despite vitamin replacement therapy, he had a poor outcome.
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Perea et al. (2020) conducted a case report in Marchiafava-Bignami disease (n=1). Vitamin replacement therapy was evaluated on Clinical outcome. A 54-year-old male with Marchiafava-Bignami disease and spinal cord involvement had a poor clinical outcome despite vitamin replacement therapy.
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