Key result
T-wave alternans and higher QTc dispersion linked to 30-day mortality in dogs with DCM.
Why the study?
QTc dispersion and T-wave alternans as predictors of mortality in dogs with dilated cardiomyopathy and ventricular tachycardia have not been fully evaluated.
Do QTc dispersion and T-wave alternans predict 30-day mortality in dogs with dilated cardiomyopathy and ventricular tachycardia?
Observational (n=60)
Do QTc dispersion and T-wave alternans predict 30-day mortality in dogs with dilated cardiomyopathy and ventricular tachycardia?
Absolute Event Rate: 85.7% vs 26.1%
p-value: p=<0.01
QTc dispersion and T-wave alternans may serve as useful non-invasive predictors of short-term cardiac death in dogs with dilated cardiomyopathy.
The study presents a comparison of the results received from dogs with dilated cardiomyopathy (DCM) that died during the first 30 d of observation and from dogs with DCM that survived the first 30 d after the ECG. No differences were noted in the duration of QT or QTc in healthy dogs and dogs with DCM. QTcd was significantly higher in dogs with DCM and in dogs with DCM, which did not survive over 30 d of observation and dogs with DCM that died after the 30th d of observation. The presence of T-wave alternans (TWA) was more frequently observed in dogs with DCM (85% of the dogs) that died in less than 30 d during the observation. QTcd and TWA seem to be a useful non-invasive diagnostic tool to anticipate the risk of cardiac death in dogs with DCM.
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Agnieszka Noszczyk-Nowak (2012) conducted an observational in Dilated cardiomyopathy (n=60). QTc dispersion and T-wave alternans vs. Survival beyond 30 days was evaluated on Presence of T-wave alternans in dogs with DCM dying within 30 days compared to those surviving beyond 30 days (p=<0.01). In dogs with dilated cardiomyopathy, the presence of T-wave alternans (85.7% vs 26.1%, p<0.01) and higher QTc dispersion (91 vs 69 ms, p<0.05) were significantly associated with 30-day mortality.
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