What question did this study set out to answer?

To determine whether metabolic differences in skeletal muscle mitochondrial capacity explain the increased susceptibility of Asian Indians to type 2 diabetes compared with Northern European Americans.

February 19, 2008DiabetesOpen Access

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

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To determine whether metabolic differences in skeletal muscle mitochondrial capacity explain the increased susceptibility of Asian Indians to type 2 diabetes compared with Northern European Americans.
Evaluated 13 diabetic Asian Indians, 13 nondiabetic Asian Indians, and 13 nondiabetic Northern European Americans matched for age, BMI, and sex (N=39).
Measured insulin sensitivity using hyperinsulinemic-euglycemic clamps and evaluated muscle mitochondrial oxidative phosphorylation capacity via mitochondrial DNA copy number, transcript levels, citrate synthase activity, and maximal ATP production rate.
Glucose infusion rates were lower in diabetic Indians than nondiabetic participants (P < 0.001) and lower in nondiabetic Indians than nondiabetic Northern European Americans (P < 0.002).
Mitochondrial DNA copy number (P < 0.02), oxidative phosphorylation transcripts (P < 0.01), citrate synthase activity, and maximal ATP production rate (P < 0.03) were higher in Asian Indians irrespective of diabetes status.
Diabetic Indians exhibited higher intramuscular triglycerides, C-reactive protein, interleukin-6, and tumor necrosis factor-alpha, alongside lower adiponectin concentrations.

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Implication

Comparative study demonstrates elevated muscle mitochondrial capacity alongside severe insulin resistance in Asian Indians, indicating mitochondrial defects do not cause insulin resistance.

Cite This Study

Nair et al. (2008) studied this question.

synapsesocial.com/papers/6aaf72b8a5af4fa898d071a2 https://doi.org/10.2337/db07-1556

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Implication

Comparative study demonstrates elevated muscle mitochondrial capacity alongside severe insulin resistance in Asian Indians, indicating mitochondrial defects do not cause insulin resistance.

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

Key Points

Discussion

Implication

Cite This Study

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

Key Points

Discussion

Implication

Cite This Study

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