Key result
Continuing propranolol until noncardiac surgery appears safe and may postpone withdrawal rebound syndrome.
Why the study?
Signs consistent with propranolol withdrawal rebound syndrome may occur when propranolol is temporarily discontinued for major noncardiac surgery, but the timing and anesthetic safety of continuation are unclear.
Does continuation of propranolol up to the time of surgery prevent withdrawal rebound syndrome in patients undergoing major noncardiac surgery?
Does continuation of propranolol up to the time of surgery prevent withdrawal rebound syndrome in patients undergoing major noncardiac surgery?
Continuing propranolol up to the time of noncardiac surgery appears safe and may help postpone or prevent withdrawal rebound syndrome.
May support continuing propranolol through noncardiac surgery; leaves open need for prospective validation.
Signs consistent with the propranolol withdrawal rebound syndrome may occur when propranolol hydrochloride administration is temporarily discontinued because of major noncardiac surgical procedures. The time course of the appearance of these signs indicates that the risk of the propranolol withdrawal rebound syndrome peaks about four to seven days after drug discontinuation. Continuation of propranolol up to the time of surgery appears safe from an anesthetic standpoint and may also help to postpone the risk of the withdrawal rebound syndrome until after oral propranolol therapy can be reinstituted.
No takes yet. Share an insight, caveat, or question.
Lee Goldman (1981) conducted a review in Patients receiving propranolol undergoing major noncardiac surgical procedures. Continuation of propranolol up to the time of surgery vs. Temporary discontinuation of propranolol was evaluated on Propranolol withdrawal rebound syndrome. Continuation of propranolol up to the time of noncardiac surgery appears safe and may postpone the risk of withdrawal rebound syndrome, which peaks 4-7 days after discontinuation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: