Why the study?
Does sudden propranolol withdrawal precipitate acute coronary syndromes in patients with stable angina?
Population
6 patients with stable exertional angina pectoris who had moderately severe angina before treatment and…
Design
Case_series
Follow-up
2 to 21 days
Authors
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Abrupt propranolol withdrawal was associated with unstable angina in these cases; hypothesis-generating for a rebound syndrome needing prospective confirmation.
Does sudden propranolol withdrawal precipitate acute coronary syndromes in patients with stable angina?
Sudden withdrawal of propranolol in patients with stable angina can precipitate severe rebound symptoms including unstable angina, myocardial infarction, and sudden death.
Edwin L. Alderman (1974) studied this question.