Key result
Continuing propranolol until CABG may protect against withdrawal rebound in severe CAD.
Why the study?
Withdrawal of propranolol before cardiac surgery has been a controversial issue regarding its safety and effects.
Should propranolol be withdrawn before aorto-coronary bypass surgery in patients with severe coronary artery disease?
Case Report (n=6)
Should propranolol be withdrawn before aorto-coronary bypass surgery in patients with severe coronary artery disease?
Continuing propranolol up to the time of coronary artery bypass surgery is recommended to avoid the potentially fatal withdrawal rebound phenomenon.
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May support continuing propranolol perioperatively in severe CAD; Level 5 data leaves open need for RCTs before practice change.
Weiner et al. (1980) conducted a case report in Severe coronary artery disease undergoing aorto-coronary bypass surgery (n=6). Propranolol withdrawal was evaluated. Continuing propranolol up to the time of aorto-coronary bypass surgery may have a protective effect against the withdrawal rebound phenomenon in patients with severe coronary artery disease.
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