Key result
WHO/ISH charts without cholesterol achieve ~88% concordance with cholesterol-based charts, minimally overestimating drug needs.
Why the study?
Total cardiovascular risk assessment tools including and excluding blood cholesterol have been developed, but their applicability and concordance in middle-income countries like Cuba needed evaluation.
Does cardiovascular risk assessment using WHO/ISH charts without cholesterol provide concordant risk estimates and drug requirements compared to charts with cholesterol in adults aged 40-80?
Population
1287 persons aged 40-80 years in Havana, Cuba
Comparison
WHO/ISH risk prediction charts with cholesterol vs without cholesterol
Design
Cross-sectional study
Authors
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Concordant estimates support cholesterol-free WHO/ISH charts in low-resource settings; leaves open prospective outcome validation before practice change.
Cross-Sectional (n=1,287)
No
Does cardiovascular risk assessment using WHO/ISH charts without cholesterol provide concordant risk estimates and drug requirements compared to charts with cholesterol in adults aged 40-80?
The WHO/ISH cardiovascular risk prediction chart without cholesterol shows high concordance (88.1%) with the cholesterol-inclusive chart, making it a viable tool for resource-limited settings without causing significant drug overprescription.
Nordet et al. (2013) conducted a cross-sectional in Cardiovascular risk (n=1,287). WHO/ISH cardiovascular risk prediction charts without cholesterol vs. WHO/ISH cardiovascular risk prediction charts with cholesterol was evaluated on Concordance of 10-year cardiovascular risk categories. Cardiovascular risk assessment using WHO/ISH charts without cholesterol demonstrated 88.1% concordance with charts including cholesterol, resulting in only a 2.6% overestimation of drug requirements.
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