Key result
Mathematical modeling of lactate kinetics theoretically clarifies exercise metabolism by overcoming in vivo limitations.
Why the study?
Theoretical approaches with mathematical modeling are needed to clarify lactate metabolism in exercise due to limitations in current in vivo experimental methods.
Mathematical modeling is a valuable strategy for understanding systemic lactate kinetics and the anaerobic threshold during exercise.
May aid lactate threshold interpretation in exercise testing; leaves open empirical validation before clinical adoption.
The recent modeling technique to lactate (La) kinetics in exercise, and its availability, application, and limitation were summarized. Two examples were come up for discussion. One is the application of the compartment model (i.e., the description by the linear differential equations) to systemic La kinetics in exercise, and the other is the current controversy on anaerobic threshold, that is, the reexamination of the several proposed models of blood La kinetics during ramp exercise. In conclusion, considering the various limitations in current in vivo experimental approach on man, the theoretical approach with mathematical modeling, as one of the major strategies, gives full play to clarify the La metabolism in exercise.
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Yoshiyuki Fukuba (1990) conducted a review in Lactate kinetics in exercise. Mathematical modeling was evaluated. Mathematical modeling of lactate kinetics provides a theoretical approach to clarify lactate metabolism during exercise, overcoming limitations of in vivo human experiments.
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