Key result
COX-2 inhibitors show conflicting effects on blood pressure but are linked to adverse increases.
Why the study?
Data from prospective studies on the effects of cyclooxygenase-2 selective inhibitors on blood pressure are conflicting, with some reporting increased blood pressure as an adverse effect.
Do cyclooxygenase-2 selective inhibitors (CSIs) increase blood pressure?
Do cyclooxygenase-2 selective inhibitors (CSIs) increase blood pressure?
COX-2 selective inhibitors may increase blood pressure, requiring caution and close monitoring, especially in hypertensive patients.
CSIs may raise blood pressure in susceptible patients; leaves open the need for definitive prospective trials to quantify risk.
OBJECTIVE: To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure. DATA SOURCES: Clinical literature accessed through MEDLINE (1966-May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension. DATA SYNTHESIS: Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs. CONCLUSIONS: Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.
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Johnson et al. (2003) conducted a review in Hypertension. Cyclooxygenase-2 selective inhibitors (CSIs) was evaluated on Blood pressure. Cyclooxygenase-2 selective inhibitors have conflicting effects on blood pressure, with several studies reporting increased blood pressure as an adverse effect.
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