Key result
Progressive lower body positive pressure increases CVP by ~2 mmHg in healthy young men.
Why the study?
The hemodynamic effects of graded lower body positive pressure in healthy young men were not fully characterized.
Does progressive lower body positive pressure alter central venous pressure and mean arterial pressure in healthy young men?
Comparison
Progressive increases in LBPP from 0 to 40 Torr vs baseline (0 Torr)
Design
Physiological study in supine position
Authors
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Modest CVP and MAP responses to LBPP in healthy men should not alter practice; leaves open baroreflex and volume regulation mechanisms for targeted studies.
Does progressive lower body positive pressure alter central venous pressure and mean arterial pressure in healthy young men?
Effect estimate: Increase of 2.06 mmHg
p-value: p=<0.05
Lower body positive pressure increases central venous pressure and mean arterial pressure through blood volume translocation and possible activation of intramuscular pressure-sensitive receptors.
Shi et al. (1993) studied Healthy (n=14). Lower body positive pressure (LBPP) vs. Baseline (0 Torr) was evaluated on Central venous pressure (CVP) (Increase of 2.06 mmHg, p=<0.05). Progressive lower body positive pressure up to 40 Torr significantly increased central venous pressure by 2.06 mmHg and mean arterial pressure to 95 mmHg in healthy young men (P<0.05).
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