Key result
Clopidogrel plus aspirin is linked to ~71% fewer post-closure migraines with aura versus aspirin alone.
Why the study?
Migraine frequency and severity increased after transcatheter closure of atrial shunts despite aspirin treatment, prompting evaluation of altered anticoagulation regimens.
Does clopidogrel added to aspirin reduce migraine with aura in patients undergoing transcatheter closure of an atrial shunt?
Comparison
Clopidogrel plus aspirin vs aspirin alone
Design
Audit of anticoagulation regimen change
Authors
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Migraine exacerbation early after shunt closure on aspirin warrants regimen caution; leaves open optimal antithrombotic strategy.
Observational (n=160)
Does clopidogrel added to aspirin reduce migraine with aura in patients undergoing transcatheter closure of an atrial shunt?
Absolute Event Rate: 12.2% vs 42.3%
p-value: p=< 0.001
Adding clopidogrel to aspirin for the first month after transcatheter closure of an atrial shunt significantly reduces the incidence of migraine with aura compared to aspirin alone.
Peter Wilmshurst (2005) conducted an observational in Migraine with aura after transcatheter closure of an atrial shunt (n=160). Clopidogrel and aspirin vs. Aspirin alone was evaluated on Migraine with aura in the first month after transcatheter closure (p=< 0.001). The combination of clopidogrel and aspirin reduced migraine with aura in the first month after transcatheter closure compared with aspirin alone (12.2% vs 42.3%, p<0.001).