Key result
Endothelial dysfunction contributes to thrombosis and hypertension by impairing anticoagulant surfaces and blood pressure regulation.
Why the study?
The mechanisms by which damaged endothelium contributes to thrombosis and hypertension through loss of anticoagulant and vasodilatory functions are not fully elucidated.
Design
Review article
Authors
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Endothelial dysfunction may promote thrombosis and hypertension; leaves open targeted therapies for prospective validation.
This review highlights the pathophysiological role of endothelial dysfunction in promoting thrombosis and hypertension through the loss of vasodilatory and anticoagulant factors.
Andrew D. Blann (2003) conducted a review in Thrombosis and Hypertension. Endothelial dysfunction vs. Healthy endothelium was evaluated. A damaged or dysfunctional endothelium contributes to thrombosis and hypertension by failing to maintain an anticoagulant surface and correctly regulate blood pressure.