Key result
Chronic periodontitis with T2DM is linked to ~3-fold higher serum apelin levels versus healthy controls.
Why the study?
This is the first study showing the co-relationship of apelin among chronic periodontitis and type 2 diabetes mellitus to investigate serum apelin levels.
Are serum apelin levels elevated in patients with chronic periodontitis and type 2 diabetes mellitus compared to healthy individuals?
Observational (n=180)
Are serum apelin levels elevated in patients with chronic periodontitis and type 2 diabetes mellitus compared to healthy individuals?
Serum apelin levels are significantly elevated in patients with both chronic periodontitis and type 2 diabetes mellitus, suggesting a potential role in inflammation and glucose regulation.
Apelin elevation in comorbid periodontitis and T2DM is hypothesis-generating; prospective studies needed before any clinical role.
Background: This is the first study showing the co-relationship of apelin among chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM). CP has an anti-inflammatory and anti-glycaemic role in our system. In the future, a localised therapeutic dose of apelin can be used to lower the severity of periodontal disease by reducing the inflammation. The objective of the present study is to investigate the levels of serum apelin from patients with CP, CP + T2DM, and healthy individuals. Materials and Methods: This study included 180 individuals that were equally divided into three groups. Group A consisted of healthy individuals, Group B with CP, and Group C with CP + T2DM. Probing pocket depth (PPD) and serum Apelin (AP) were measured. Serum apelin expression was determined using enzyme-linked immunosorbent assay. Statistical analysis was performed using SPSS software. Results: The highest apelin was in CP + T2DM group (24.0 ± 3.78 ng/dl) followed by CP (15.4 ± 2.01 ng/dl) and healthy individuals (7.6 ± 1.18 ng/dl). There was a significant increase in serum apelin (P ≤ 0.05) in Group C individuals. Similarly, PPD was significantly increased in individuals with CP + T2DM. Conclusion: Expression of significant apelin in patients with CP and T2DM suggests a possible role for these adipokines in inflammation and glucose level regulation. In the future, it may be used as a therapeutic agent in curing periodontitis.
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Kumar et al. (2020) conducted an observational in Chronic periodontitis and type 2 diabetes mellitus (n=180). Chronic periodontitis and type 2 diabetes mellitus vs. Healthy individuals was evaluated on Serum apelin levels (p=≤ 0.05). Chronic periodontitis with type 2 diabetes mellitus was associated with significantly higher serum apelin levels (24.0 ± 3.78 ng/dl) compared to healthy controls (7.6 ± 1.18 ng/dl; P ≤ 0.05).
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