Key result
Children with type 1 diabetes mellitus had significantly increased circulating apelin levels compared to healthy controls, with no correlation to BMI, lipids, or insulin sensitivity.
Why the study?
Do children with type 1 diabetes mellitus have altered blood apelin concentrations compared to healthy controls?
Case-Control (n=75)
Do children with type 1 diabetes mellitus have altered blood apelin concentrations compared to healthy controls?
Children with type 1 diabetes mellitus have significantly elevated circulating apelin levels compared to healthy controls, though these levels do not correlate with standard metabolic markers.
Elevated apelin in pediatric T1DM without metabolic links is hypothesis-generating; leaves open biomarker or mechanistic roles pending prospective studies.
BACKGROUND: Apelin is a novel adipocytokine produced by white adipose tissue that binds the APJ receptor with high affinity. Insulin may have a role in regulation of apelin synthesis and secretion from the adipose tissue. OBJECTIVE: To investigate blood apelin concentrations in children with type 1 diabetes mellitus (T1DM) and display association of apelin with adiponectin, body mass index (BMI), lipids and insulin sensitivity. METHODS: Thirty patients with T1DM and 45 healthy controls were enrolled. Apelin levels were measured along with BMI, lipids, fasting plasma glucose, HbA1c and adiponectin levels. RESULTS: Plasma apelin and adiponectin levels were significantly higher in the diabetic group when compared to controls. No correlation was found between the apelin blood concentrations and adiponectin, BMI, lipids and insulin sensitivity. CONCLUSIONS: Children with T1DM have significantly increased circulating apelin levels when compared to healthy controls. However, no significant relation was found between the apelin and BMI, glucose, lipids and adiponectin levels, and also insulin sensitivity.
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Meral et al. (2010) conducted a case-control in Type 1 Diabetes Mellitus (n=75). Type 1 Diabetes Mellitus vs. Healthy controls was evaluated on Plasma apelin concentrations. Children with type 1 diabetes mellitus had significantly increased circulating apelin levels compared to healthy controls, with no correlation to BMI, lipids, or insulin sensitivity.
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