Key result
AIDS is linked to a 28% prevalence of cardiovascular autonomic dysfunction versus uninfected individuals.
Why the study?
The effects of HIV on cardiovascular autonomic function have been little investigated in African patients.
Is HIV infection associated with cardiovascular autonomic dysfunction in African patients?
Cross-Sectional (n=75)
No
Is HIV infection associated with cardiovascular autonomic dysfunction in African patients?
HIV infection, particularly at the AIDS stage, is associated with a high prevalence of cardiovascular autonomic dysfunction in African patients, highlighting the need for precautions during invasive procedures.
Answers are grounded in this paper and cite their sources.
Autonomic dysfunction may warrant evaluation in advanced HIV in Africa; cross-sectional data leave open prognostic value and need for prospective validation.
The effects of human immunodeficiency virus (HIV) on cardiovascular autonomic function have been little investigated in African patients. We performed standard heart-rate and blood pressure tests on 75 consecutive consenting patients referred for an HIV test in Yaounde, Cameroon. 54 patients proved to be HIV-infected (30 having progressed to AIDS). Cardiovascular autonomic dysfunction was present in 8 (28%) patients with AIDS and in 1 (4%) HIV-positive patient without AIDS; no HIV-negative individuals had abnormal results. If borderline results are included, over 80% of HIV-positive patients had cardiovascular autonomic dysfunction. In HIV-infected patients, simple tests such as blood pressure responses to standing or handgrip can warn of cardiovascular autonomic dysfunction, thus signalling the need for added precautions when invasive procedures are proposed.
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Nzuobontane et al. (2002) conducted a cross-sectional in HIV infection (n=75). HIV infection vs. HIV-negative status was evaluated on Cardiovascular autonomic dysfunction. Cardiovascular autonomic dysfunction was present in 28% of patients with AIDS and 4% of HIV-positive patients without AIDS, compared to 0% in HIV-negative individuals.
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