Key result
Treated HIV is linked to ~4-fold higher prevalence of autonomic dysfunction vs. uninfected controls.
Why the study?
Do HIV-infected patients on stable combined antiretroviral therapy report higher frequencies of dysautonomia symptoms compared to HIV-negative patients?
Cross-Sectional (n=70)
No
Do HIV-infected patients on stable combined antiretroviral therapy report higher frequencies of dysautonomia symptoms compared to HIV-negative patients?
HIV-infected patients on stable antiretroviral therapy experience a higher burden of dysautonomia symptoms across multiple domains compared to HIV-negative individuals.
Autonomic symptom screening may be warranted in stable HIV patients on ART; leaves open causality and need for prospective validation.
This retrospective study evaluated the frequencies of symptoms associated with autonomic dysfunction in human immunodeficiency virus (HIV)-infected patients on stable combined antiretroviral therapy. Patients infected with HIV reported higher frequencies of dysautonomia symptoms compared with HIV-negative patients, particularly in the autonomic domains related to urinary, sleep, gastroparesis, secretomotor, pupillomotor, and male sexual dysfunction.
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Chow et al. (2015) conducted a cross-sectional in Human Immunodeficiency Virus (HIV) (n=70). HIV infection on stable cART vs. HIV-negative controls was evaluated on Clinically significant autonomic neuropathy (COMPASS score ≥30) (p=.010). HIV-positive patients on stable suppressive combined antiretroviral therapy exhibited a significantly higher prevalence of clinically significant autonomic dysfunction symptoms compared to HIV-negative controls (40% vs 9%, P = .010).
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