Why the study?
Differences in heart rate response to autonomic blockers between ethnic groups and the role of pharmacogenetic sensitivity were unclear.
Does the heart rate response to autonomic blockers differ between Bushmen and White volunteers?
Does the heart rate response to autonomic blockers differ between Bushmen and White volunteers?
Ethnic differences in heart rate response to atropine may be driven by inequalities in baseline vagal or sympathetic tone rather than direct pharmacogenetic sensitivity.
Answers are grounded in this paper and cite their sources.
May reflect pharmacogenetic differences in autonomic tone between populations; hypothesis-generating for individualized blocker responses.
The influence of autonomic blockers on the heart rate of ten Bushmen and eight White volunteers was studied. There were significant differences in heart rate response to atropine alone between the White's and Bushmen. However, after prior beta-adrenoceptor blockade, these differences were no longer significant. It is postulated that a varying pharmacogenetic sensitivity to autonomic blockers may result from inequality of vagal or sympathetic tone.
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Meyer et al. (1990) studied this question. Autonomic blockers (atropine and beta-adrenoceptor blockade) vs. Between ethnic groups (White vs Bushmen) was evaluated on Heart rate response.
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